A new study published in the journal Nature found that genetics plays a bigger role in the development of obesity than was previously thought. Researchers from the University of Michigan unveiled the results of a genome-wide association study looking at body mass index (BMI), a common measure of obesity, in close to 400,000 individuals (Nature, 518:197-206;February 11, 2015).
This new research finds that as much as 21% of BMI variation can be accounted for by genetics. There are about 100 locations across the genome that plays roles in various obesity traits, double than what was previously thought.
“This research may help determine who is at risk of developing diseases associated with obesity and may lend insight into future treatment,” says Elaine Trujillo, nutritionist and author of The Calories In Calories Out Cookbook. “We have known that one size does not fit all when it comes to weight gain, development of risk factors and even obesity treatment. Now we have more research to support that notion,” Trujillo adds.
According to Caroline Apovian, Professor of Medicine and Pediatrics and the Director of the Nutrition and Weight Management Center, Boston Medical Center, Boston University, “For those of us treating obesity, this is exciting news because particular genes and pathways affecting BMI have been implicated that respond to changes in eating behavior. Once we can figure out which of these genes are implicated in each patient, we can tailor the treatment of their obesity based on their particular genetic profile. For example, one of the pathways implicated in this paper is one that is the proposed mechanism of action of the combination of drugs recently approved by the US Food and Drug Administration for treatment of obesity – topiramate/phentermine. Based on genetic profiles, we may be able to predict which patients will be successful at weight loss with this particular drug combination (topiramate/phentermine) as opposed to another treatment if they have this pathway variation. Also, we may be able to predict who will do well with bariatric surgery in the future.”
In a companion paper on waist-to-hip circumference ratios, 49 sites in the genome were identified (Nature 518:187-186; February 12, 2015). The waist-to-hip ratio and waist circumference alone are used to determine fat distribution and abdominal fatness and is a marker for developing diseases associated with obesity. Men who have waist circumferences greater than 40 inches and women who have waist circumferences greater than 35 inches are at higher risk of diabetes, dyslipidemia, hypertension, and cardio-vascular disease.
Much more research is needed to determine how the genetic variations in individuals lead to weight gain in some and not in others. Some of the genes involved in obesity may be related to other diseases, this research is a step in uncovering the biological basis to a whole host of metabolic diseases. Although genetic background may be a useful tool in the future for developing personalized diets for weight loss and health, those ...Read More
These days, airfares change often and it is therefore challenging for travelers to find the best deal. Most travelers wish to get cheap air tickets and the common question they have in their minds is how to save money on airfare. This is particularly the case from frequent travelers because they may end up spending too much money on airplane travel. The following are tips on how to find the best deals on flights.
Signing up for airfare alerts is the first step you need to take. Listing and travel search websites offer them free. They will send you emails informing you about the reduction of airfares. Some sites will inform you when the airfares on a particular route you have chosen reduce in price despite the airline or flight time.
You can also get good deals on air travel if you sign up for frequent flier programs and emails from different airlines. Airlines always try to attract customers to book with them directly by offering special deals after they sign up for their email lists and newsletters. They may provide you with a promo code deal that you can only redeem on their websites. An airline can also alert you on special deals available to members of its loyalty program.
If you are a flexible flyer, you can also pay low airfares. Be flexible on arrival and departure times, travel dates and destinations if possible. Different price levels exist for every flight. The factors that affect the prices of flights include the date when a ticket is bought, the popularity of the destination, the travel season and how full a flight gets.
Another thing to can do to get good deals on flights is to book travel tickets early. Most airlines offer the best fares to travelers who buy tickets, 24, 14 or 7 days before the day of the flight. It is also possible to get a good deal if you are creative as you search for flights. You can check how much various airlines are charging based on connection and schedule.
Opting for travel packages while travelling for a vacation is a great idea because such packages normally include hotel, air travel and car rental costs. The money you will be charged for the total package will be lower than what you would have paid for the services separately. Using your frequent flyer points or miles can also help you save on airfare. A great way of spending these points is paying for long distance trips.
Another way to pay less on a flight is to call a travel agent and ask him or her to help you find a package deal. Travel agents always know about the airlines that are offering the cheapest tickets to various destinations. Even though they will charge you for their services, the savings you can achieve can be tremendous.
After they find a cheap ticket, travelers should obtain information about the extra fees that they may be required to pay for premium seats and luggage among other things. ...Read More
Whenever an individual wants to buy Silke products, they will always look for the most appropriate way through which they can get that which matches them. There are those who do not have the kind of your energy and effort to invest on factors that do not even add value to their perform. If this is what you are looking for, you should consider buoying them online.
Indeed, you are likely to discover many sites that offer such products. Just use any of the results and you will be confused by the outcomes that will appear. This should be a god factor considering that it gives you an probability to select what you like best. However, this has not always been the situation as many individuals grumble that they can hardly discover what they need.
One of the factors why such individuals cannot get the kind of products that they need is because they hardly comprehend the actions that need to be followed so as to history great outcomes. There is no way you can just get online and buy factors anyhow and anticipate that they will be excellent. This will only create you to end up with plenty of issues that could have otherwise been prevented.
Indeed, there are individuals who look for some of the well known companies and just continue to select any of the results that they discover. They go forward to pay and purchase for products without even understanding what they are spending for. Even though a individual may be fortunate to get excellent products, professionals have always outlined that the possibilities of achievements are little.
It is excellent to take a while and know what you exactly need. When it comes to purchasing these types of products, one factor that is for sure is that everyone will always have that which matches them best. There always are many factors why everyone looks for such products and therefore, you need to be sure about what is appropriate for you before creating options.
Do not get puzzled by the point that the online world is loaded with plenty of products that a customer like you can select from. Some customers even believe that everything that comes their way will be excellent. However, this is not always the situation because in many circumstances, individuals often end up with factors that are not even near to what they desired.
Always go for top great quality products. Once you get to any web page, you will see that the products shown come with different types of functions. Some of them will be of top great quality while others will not be excellent. Therefore, you need to select that which will quickly help you to achieve the objective for which you made the decision to buy them.
In such a scenario, you will only be able to buy excellent Silke products if you discover an honest supplier. Do not just go for anyone that can be discovered because you never know what to expect from ...Read More
The future of manufacturing, printing, as well as packaging industries depends on how the present processes are streamlined to reduce energy used, gases emitted and hazardous substances released in the final product. Sustainability has gone beyond using recycled paper, input materials, and ink in the process of printing. More sustainable digital printing practices have to be adopted to secure the safety and happiness of the next generation.
Location of any industry plays crucial role in sustaining most of its processes and securing a large number of customers. It is therefore important for a firm to operate where it enjoys large market benefits. A firm can reduce transportation cost through promoting deliveries on foot and pickups. Such initiatives developed by industry players ensure reduction in air pollution. In addition, operating cost will be reduced allowing healthy competition with other firms.
Sustainability goes far beyond the actual production processes. All the activities carried out within the company assist in ensuring a better future and being able to survive during tough financial situations. As a result, the company should provide reusable bottles, dishes, and containers in the lunchroom. The practice will see a healthy and good working environment and a reduced solid waste management.
The drying chamber in the printing process consumes much energy which can be eliminated through two ways: redesigning of various units, and applying the latest technologies. Production units should be streamlined from least to highest energy use. Current technologies applied include having enhanced drying unit which removes moisture, leaving the warmth needed to maintain the right temperature in the chamber. Additionally, companies ought to embrace the use of print that uses little water as possible during various processes and reduction of emission of harmful substances which can possibly endanger workers and impacts negatively on the environment.
Companies dealing with production of equipment have to uphold quality. Quality dictates its lifespan. It is possible to produce products which will only require little maintenance for as long as a few decades to come. Production of quality equipment will not only see their survival in the market. It will also reduce the release of a harmful substance when early disposal could have been made. It is evident that priority has to be given product quality.
Various stock control methods can be used to minimize wastage and enhance production processes. Printing firms should utilize print on demand method to lower its operating cost. Other things to be championed for sustainability in these industries are the method of packaging. They can employ scrap papers for packaging once the order has been completed.
Another important sustainability aspect relies on the banner printing and reprographic projects. Companies can settle on biodegradable PVC for banners to improve on their waste management and ensuring consumer friendly product. One of the big tasks for any company is how to deal with technical reprographic projects such as engineering drawings and building plans. By utilizing current technology, a company is able to deliver a great percentage of recycled material on such projects.
If you are picking any books that you think of reading, there may be things that may have to be considered. There may be plenty of things that can greatly impact your own decisions. Still, there are numerous tips that may be used in order to obtain the book that may be right for you. Additionally, this Kismet series may really be a wonderful book that you may try on.
The genre you would be selecting would certainly be an essential factor that you must consider. Typically, this would depend on the age range and the emotions of a reader. Yet, there would be some varieties that you could select from. Still, you must be extra careful in making these decisions.
There would be some audience that would greatly catch the interest of a particular book. Romance or love would definitely be a hit for all young at heart. However, there will be people who may be of higher age who still seem to be interested in these novels since these are enjoyable to read.
There are some that will contain important facts that can be used for the daily activities of a person. There will be many that are incorporated into the books that are used in the schools since these are helpful in the entire learning process of the students. These will often discuss some stories that are of relevance to the history and culture of a certain country.
The action, horror and suspense are among the many genres that are appreciated by the people. These are extremely interesting since there will be many scenes that people can easily relate. Normally, a person will love these stories because they will see themselves into it and can relate with the casts.
Many stores nowadays are selling these items at an affordable price. These can be seen all over your place especially in the bookstores. These bookstores will definitely have a wide array of choices that will be offered for the bookworms. They can provide some other resources as well that will be useful for the consumers.
Today, there would be plenty of series that could be turned into movies since it has excellent work quality. Some of these may surely catch the attention and appeal a greater audience. Still, there may be circumstances that such details that would be stated in any novel may vary from the real movie.
There would be some benefits that you could get in reading these stories. Apart from improving your vocabulary, you would certainly learn new things or facts. Additionally, there would be high possibilities that you could get many ideas regarding handling several situations that might happen to you.
These Kismet series would be a good example of some books that can be appreciated in the modern era. These could be purchased through some online stores and have it delivered at a particular rate. Yet, you must be extra careful in selecting these so that you would not be associated with some fraudulent activities. You must conduct an ...Read More
You have just read an entire collection of novels from your favorite novel. Reading being one of the most important pastimes that you do for relaxation, you have decided that it is about time for you to start looking for options and choices that would gibe you a good, pleasurable read again. Right now, you re into finding the best contemporary romance authors.
Most women reader really love the idea of reading about the pains and the pleasures of falling in love. No wonder, these kinds of stories do tend to have a very good niche for those writers who would want to use their opens towards crafting stories of this type. Of course, you have to make sure first that the book you are getting this time is really a good read.
Always make sure that you pick up good books. If you love reading and you enjoy reading, then you want the stories that you will be reading to be really good ones as well. You need them to be stories that happen to have depth and character development, and a good plot. Without these elements you are likely to be going nowhere with the novel you have picked up.
Never waste time in books that do not give you anything but a disappointing read. You can never really get back the wasted time you have to spend in reading a disappointing story. So, always be very careful before you turn the first page. Also, buying a disappointing read will be such a waste of your resources especially when you could have used the same amount to buy a better story.
It helps that you will find ways on how you can spot a good writer, there are various steps that you can take to ensure that the author you will be referring to moving forward is always going to give you a very satisfying read. There are points that you might want to look into and factors that you might want to take into account so you are confident that you can easily choose right at the end of the day.
Finding a good author these days can be real tough, with the number of names that have emerged in this field, it is always easy for really good ones to be buried under the more glittery names of those that have the right financial backing for their published works. But with the right perseverance and the right drive, you can easily end up with great finds from the wide array of choices you have.
Consider the excerpt of the story that you are interested on. Before you will buy any of the works of these writers, you want to know first what it is that they have on store for you the moment you decide to open the first pages. So, what you can do is to read the excerpt. Thus, you can easily tell if the story they are working on is engaging enough and would be a worthy read for ...Read More
Businesses are very essential in any economy. They can refer to any organizations that are involved in different commercial activities of selling products and services. One major important commercial activity is selling of food and offering accommodation services. There are several businesses that offer these services to the people in the society but there is one incomparable place like Silke restaurant.
These facilities offer more than just meals. Modern facilities offer accommodation services. If one was traveling, they do not have a reason to worry since they can sleep over at these hotels. They have magnificent rooms that will keep the customer entertained especially with the televisions and computers. This is not to forget the bedding and room design that are comfy enough to make the customer really warm and comfortable.
Since people are living in a new era, things are pretty different from the past. Modern restaurants are uniquely designed with the best accommodation facilities for their clients. One can visit a near restaurant and see all they have to offer. One other good thing regarding their services is the decent meals they offer and an ample space for parking cars that visitors come with.
It is now a common thing for these facilities to have entertainment for their customers. Cultural dances and musical performances characterize the place. Most people love these performances since they make the environment lively especially when they are taking a meal. With this, one can bet that these hotels make a big deal of money.
These places also offer entertainment to their customers. Usually, there are people like dancers and acrobats in these hotels to entertain the visitors who love them so much. Cultural dances and singing are common, and since many people love them, restaurants get many clients and are able to be a success to not only give better services to the community but also improve lives especially for those who work with them. The economy is also able to be boosted by their performance.
Unemployment has crippled many economies of the world especially by the big number of population which is always on the rise. The hotel facilities in question have tried their best to create opportunities for the people in the society. There are managers, waiters, entertainers, and may other staff that work with the hotels. They are all able to earn a living and improve their life through the hotel commercial activities. Given their big number in the society, they have even absorbed many people to work for them.
These hotels are the perfect places for couples and those who are starting relationships. It is common to see people who are dating to these places. This is because, they are now known as classy places where people can have private time and share a meal while they are trying to get to know each other better.
The final word is that the Silke facilities are a basic thing. One never knows when they will get stuck in some area or get lost, only for ...Read More
The road to success for award winning authors is not a simple one. Anyone aiming to be in this number needs to be prepared to work extremely hard and rise over rejection. These tips are a great starting point to help you achieve those goals.
Writing skills, like muscles, need to be used often or they lose their form. Just like an athlete trains every day to improve their skills, so should a writer. The more you write the easier it becomes to produce quality content, deserving of praise. When you are felling uninspired, just look around you. You can surely find a story in many places such as a picture, a sculpture or watching people in the mall.
With so many methods and techniques available, it is incredibly important to take the time to learn more about your craft. This valuable information is easily acquired through attending classes, courses and seminars. While many of these are paid for, there are also free community and online courses available. This is a great opportunity to receive feedback on your writing, be introduced to a variety of tones and acquire methods that will work best for your style.
It’s all very well writing your heart away but if there is no publication, it’s a wasted effort. Although exposing your work is no easy task, this strenuous process is vital to success. Working through a big publishing firm, places many elements out of your hands. So, it is imperative that you are comfortable with the publisher and editors you are working with. They should be in alignment with your vision and goal.
If in doubt, publish it yourself. Authors don’t always have to go the route of a big publisher. Self-publishing is available as an option and with many platforms emerging for new writers, it’s one that more people are considering. This option essentially removes the middle man and places responsibility for all aspects of production on the author. This includes writing and editing the content; designing the book cover and layout; and controlling the distribution and marketing of the work.
Rejection is a reality in this industry. As demoralizing as this many be, find a way to deal with rejection. Any author will tell you that they received many rejection letters before they finally got an acceptance. This is a rite of passage, part of the process for anyone looking to succeed. Anyone putting their literature out there needs to build that thick skin and persevere. The important thing is to keep trying.
There are many competitions that cater to emerging writers, poets and journalists. Enter as any competitions as you can. This is a great opportunity to get comments and feedback on your work, particularly from the judges who are often active members of the publishing industry. Besides helping you get your name out, some contests have paid prizes which may be a great incentive to keep moving forward.
Resumes are some of the things which explain to the employers about the employee they are about to higher. When writing, it is advisable that you should contact an executive resume writer and seek for guidance on how to go about writing it. This article provides some ways on how to go about it by indicating some of the important information to include.
The first step is thinking details. Before settling down to write, you must first of all think on what you want out of the resumes. You should write it in a way that it targets the position you are applying for. This involves not only listing the abilities you have, but showing how those abilities are relevant to the position you are applying for.
The first thing which must clearly be indicated is the contact information as well as the biodata of the applicant. The intention of writing the curriculum vitae is for the potential employer to contact you to inform you to attend an interview. The contact information is therefore an important thing to consider and you must ensure that you can be reached easily from the contact. If you have different telephone numbers during the day and a different one during the night, you must clearly indicate this in your curriculum vitae.
After giving the contact information and the biodata, the next thing is to come up with a short paragraph which indicates the skills one possesses. The paragraph should also include the expertise you have as well as any other thing which you poses which is unique and would make you to out stand among the other also applying.
Your achievements are also important as well. This sis because most of the time, you will be judged by the achievements you have achieved in your career. You may have worked in different places but of all the places there is nothing you have achieved.
As well you may have worked only in one place but you have achieved a lot of things. These must be demonstrated clearly. Other than the achievements, you must also give a brief history of the places where you have worked. This will also explain the skills and experience you have acquired during the time he worked. While stating your work history, you must also include stating the responsibility you have held over the years as well.
Membership to various organizations as well as the positions you have held in them is also important information to include. You must also be consistent with the way you write. If you have adopted a particular writing style, you must continue with the same style.
The resume should be sent together with a cover letter which gives an introduction about your career and your intention to apply for the position advertised. These are some of the steps executive resume writer undertake when writing resumes. The steps may also be important to any other person who may wish to write their own resumes.
The new urban fantasy genre is really all that new to the minds of writers. There has generally been a small group of writers that see the many magical possibilities within the contemporary world setting around and always try incorporating it into their style of writing. The Jill Kismet series novel is a good example of this style of writing with a contemporary urban fantasy.
The urban fantasy novel is generally a story that takes place in the real world type urban settings that many people would recognize easily. Inside this world different magical components are integrated that are often hidden from regular people and are the main driving force within the story. Though there are times where magic or its many possibilities are accepted by mainstream society. This is generally not typical of most novels.
The story’s plot often revolves around a female protagonist that faces many obstacles while coming to terms with their background and identity. There is often a romantic sub-plot as well that provides an insight to the character’s strengths and weaknesses. Many times it ultimately proves to be a central point for the character when deciding what path to take to better understand themselves.
The novel Night Shift follows this simple formula. It is the starting novel for the Jill Kismet novels by author Lilith Saintcrow. She is most known for the Dante Valentine the female bounty hunter series. There are some basic similarities between them, but Night Shift also has many refreshing differences.
Jill is a new character that dwells in a more modern world instead of the futuristic world. Its also a darker world with darker sub-text involving the influences of the forces of good and evil. Many monsters and bad guys exist there that are often lurking around the any corners that she must deal with called the hellbreed. They often prey on the weak and innocent and Jill’s mission is to protect innocent people and stop the hellbreed.
To do this she uses the typical assortments of knives, swords and guns that any self respecting demon hunting good guy would have. She also wears light leather armor which protects her from being hurt. Added to these is a demon mark branded on her that she bartered with the top hellbreed in her city for. It adds several superhuman powers to her so she can go and do more than a regular person.
As you go deeper in the book you recognize that Jill is like a female version of a liquor drinking Rambo. Often her motives or actions are centered more around vengeance rather than simple justice. This plays well into the ideas of good vs evil and whether it is just a choice or what you are born like. Written as a first person narration, many readers will ponder these ideas as Jill’s past is carefully revealed through various flashbacks and her self-questioning sequences inside the story.